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Transderm® Ionto System
A New Science in Skin Care®
Official
presentations:
AAD, Washington D.C., Feb. 06 - 11
Dermoelectroporation®:
A New
Iontophoresis
Concept
From the
past....
In
Iontophoresis procedures,
it is well known that in order to avoid changes in skin pH, it is
necessary to have a two-step procedure.
In
the first step, negative ions are introduced into the skin.
In the second step, the polarity is reversed and positive ions are
introduced.
At the end of
this procedure, the skin pH should be balanced; but some changes in pH may still
occur during the treatment, causing skin irritation.
For this
reason, it is typically not recommended to perform a microdermabrasion before a
traditional Iontophoresis treatment; although
the reduction of the stratum corneum layer, resulting from
microdermabrasion, offers faster transdermal drug delivery and higher
repeatability.
…To
the Future
Mattioli
Engineering Labs discovered that by providing a continuous reversed
polarity current, controlling the average pulse value, and varying the
pulse shape according to the skin’s specific electrical impedance,
transdermal delivery of drugs occurs as in classical Iontophoresis,
despite the fact that the average current is zero.
Moreover macromolecules, like collagen, are transdermally deliverd for
the first time ever.
The
absence of temporary pH change allows for the use of microdermabrasion
before treatment. Pre-treatment
microdermabrasion boosts the transdermal delivery rate and
ensures repeatability as a result of the standardization of the
thickness and permeability of the stratum corneum.
The
pulse shapes are similar to
electroporation pulses, but operate at a much lower energy
and penetrate even under high skin impedance conditions.
For these reasons, Mattioli Engineering named this new patented
proprietary technology
DERMOELECTROPORATION
®.
University
Trials and Clinical Studies
Studies
performed on Dermoelectroporation®by the University of Florence (Italy)
labs, evaluated the effects of transdermal delivery of radioactive
Lidocaine into the skin.
The
study proved that, by using the Dermoelectroporation®
technique, Lidocaine molecules can be delivered into the dermis
after microdermabrasion at a higher rate - applying the same dose - than
by using classical Iontophoresis, with no adverse effects.
Relative
value of radioactive Lidocaine delivery Graph.
Dose-response
curve Showing the comparison between
Iontophoresis and DermoelectroporationÒ.
An
exciting new frontier
DERMOELECTROPORATION®
technology can be used with approved ionic solutions for Iontophoresis.
In addition, the zero average current offers opportunities for
application and use of all types of ionic solutions, due to the absence
of electrolytic reactions at the electrodes.
Clinical
trials are currently demonstrating the possibility to obtain, for the
first time ever, transdermal delivery of macromolecules like collagen;
this suggests potential future applications of new types of substances
impossible to deliver by classical Iontophoresis.
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Laboratory
test. Ionic solution of Fluorescent Collagen on the
dermis
after 8 minutes without dermoelectroporation
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Laboratory
Test. Ionic solution of Fluorescent Collagen delivered
into
the dermis after
8 minutes dermoelectroporation
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What
makes Dermoelectroporation® technology different?
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Capability of Transdermal Delivery of any type of
ionic solution of active substances
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Capability of Transdermal Delivery of ionic solution
of macromolecules
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No electrolytic degradation of biologically active
molecules
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Boosting of transdermal delivery rate by means of
microdermabrasion and pulse delivery
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No variation in the skin’s
pH.
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Reproducibility of dose delivered
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Non-invasive action. No Trauma from injections.
Dermoelettroporazione U.S.
Patents 6,535,761 - 6,482,212 - 6,409,736 - 6,368,333 - 6,322,568 -
6,306,147 - 6,149,634 - 6,120,512 - 5,954,730 - Other
patents pending
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